Adult onset disease. Imaging tests can reveal damage caused by the disease.

Adult onset disease Blood tests can help rule out other conditions that have similar symptoms. Elderly-onset Still’s disease (EOSD) is reported in some cases, commonly in Japan, the USA and Europe. Objectives: Adult-onset Still's disease (AOSD) is a rare condition characterized by fevers, rash, and arthralgia/arthritis; most doctors treating AOSD in the Netherlands treat <5 patients per year. The disease affects multiple organs and systems and has a variable clinical presentation [1]. Temperature of ≥39℃ for ≥1 week. Introduction. Chronic progressive external ophthalmoplegia (CPEO) is the most common specific manifestation of mitochondrial disease, and is considered to be present in approximately 20% of patients presenting in adult life. The primary difference between the two conditions is the age when symptoms begin. One of the most commonly used criteria for diagnosing The so-called adult form of Pompe disease is not an autonomous entity with respect to the classic and juvenile ones, but differs from them mainly for the lower speed of accumulation of glycogen within the lysosomes which explains the late onset of Adult-onset Still's Disease is a rare, idiopathic, inflammatory disorder characterized by arthralgia, evanescent, salmon-colored rash, and daily fevers as well as lymphadenopathy, pharyngitis, splenomegaly, myalgias, and serositis. The inciting etiology of this syndrome is unknown, though it has been hypothesized that infection triggers an JIA. Macrophage and neutrophil activation is a hallmark of AOSD which . Typical rash. Methods: The CPG committee for ASD organized by the Research Team for Autoimmune Specific clinical features in ‘suspected mitochondrial disease’ Key neurological features of mitochondrial disease are outlined in Table 1. Adult-onset Still’s disease typically affects adults under age 35. It is usually characterized by high spiking fevers, arthritis, and an evanescent, nonpruritic, macular and salmon coloured rash, appearing on the trunk and the extremities. Adults may appear normal for the early part of their lives before symptoms develop. The purpose of this study was to demonstrate that MR imaging allows identification of cases of AD with adult onset (AOAD), which are remarkably different from infantile cases. The pathogenesis of AOSD is not completely recognised. The disease is considered a diagnosis of exclusion. Progression is slow with periods of rapid deterioration. This type of Pompe is characterized by symptoms that include slowly progressive respiratory problems and skeletal muscle weakness. JIA affects one in 1,000 children. It is frequently underdiagnosed and one of the main reasons for hospital Adult-onset Still’s disease is a rare inflammatory disorder usually affecting young adults. Vrij zeldzame aandoening met aanvallen van (zeer hoge) koorts, lichte huiduitslag en keelpijn, gewrichtspijnen en soms uitgesproken gewrichtsontsteking. It is frequently underdiagnosed and one of the main reasons for hospital admissions due to fever of unknown origin. The clinical course varies and can be monocyclic, polycyclic, or chronic with either systemic or articular symptoms predominant. Owing to its sporadic appearance in all adult age groups with potentially severe inflammatory onset accompanied by a broad spectrum of disease manifestation and complications, AoSD is an unsolved challenge for clinicians with Late-onset (juvenile or adult-onset) Symptoms of late-onset Pompe disease can appear at any age — before 1 year of age but without an enlarged heart (which distinguishes it from infantile-onset), later in a child’s life, during adolescence or in adulthood. Parkinson’s disease or multiple sclerosis cause many similar symptoms. Prevalence . Symptoms. 16 to 0. These types of diseases appear in adults Adult-onset Still’s disease (AOSD) is a rare inflammatory disorder that has been recently classified as a polygenic autoinflammatory disorder. Imaging tests can reveal damage caused by the disease. Most types of ANCL are inherited in an autosomal recessive manner. Variants in ubiquitin-related genes, previously implicated in autoinflammatory disease, may define new disorder Adult-onset Still's disease (AOSD) is an inflammatory disorder of unknown origin, occurring in patients older than 16 years and characterized by high fever, arthralgia or arthritis, an evanescent salmon-colored skin rash, and leukocytosis with neutrophilia. First described in 1971, adult-onset Still's disease (AOSD) is a rare multisystemic disorder considered as a complex (multigenic) autoinflammatory syndrome. Currently, there is no internationally accepted treatment guideline for AOSD. Other symptoms include an enlarged spleen and lymph nodes, joint pain, and sore throat. 4/100,000 [1]. Causes. It differs from classical rheumatoid arthritis in that it is more often marked by acute febrile onset, and generalized lymphadenopathy and hepatosplenomegaly are What is adult onset Still's disease? Adult-onset Still’s disease is a rare immune-mediated, multisystem inflammatory disorder indicated by the “Still’s triad” of high spiking fevers, rash and arthritis (joint pain). Systemic-onset rheumatoid arthritis in adults. It is also called adult-onset Still disease (AOSD). Adult-onset Alexander disease. Komt vooral bij jonge mensen voor, zelden na de leeftijd van 40 jaar. Of note, echocardiography alone (without specific measurement of the Adult-onset Still's disease (AOSD) is a rare systemic autoinflammatory disorder of unknown aetiology with an estimated prevalence of 0. Adult-onset Still’s disease (AOSD) is a rare inflammatory disease with an unknown cause . Indeed, an international consensus group has recommended using the term "Still's disease" to describe both sJIA and AOSD. et al. Bibliographies, textbooks, and websites of recent rheumatology conferences Systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease (AOSD) are considered the same disease, but a common approach for diagnosis and management is still missing. In JIA, autoantibodies target healthy joint cells and tissues. Adult-onset Still disease (AOSD) is a rare multisystem autoinflammatory disorder that typically affects young adults. The reason behind the nomenclature of this condition is that AoSD shares certain symptoms with Still's disease in children, currently named systemic-onset juvenile idiopathic arthritis Diagnosis. Adult-onset Still’s disease (AOSD), first reported by Eric Bywaters in the 1970s (), is a rare disease with unknown etiology that affects multiple systems and organs. At The key terms, adult onset Still's disease, AOSD, adult Still's disease, ASD, Still's disease were used to search Medline (1966–2005) and PubMed (1966–2005) for all available articles in the English language. Some have obvious signs and symptoms of Gaucher disease early on, while others have a mild form of the disease or no symptoms at all. The central role of macrophage Adult-onset Still disease is a seronegative disease meaning a negative rheumatoid factor and antinuclear antibodies are commonly found. While much less common than the childhood form, Still’s disease can also occur in adults, causing joint and Adult-onset Still’s disease (AOSD) is a rare systemic, autoinflammatory disorder that often presents in adolescence and early adulthood with fever, rash, and polyarthritis. , . A genetic background would confer susceptibility to the development of autoinflammatory reactions to environmental triggers. Lambert-Eaton syndrome. Adult Still disease is a rare type of inflammatory arthritis. With the licensing of interleukin (IL)-1 inhibitors, effective treatment options have become Abstract. Diagnosing AOSD is challenging as Adult-onset Still's disease (AOSD) is an uncommon systemic inflammatory disorder characterized by inflammatory polyarthritis, daily fever, and a transient salmon-pink Adult-onset Still’s disease is a rare type of inflammatory arthritis. A case of AOSD in a 73-year-old woman with a non-classic presentation, Abstract. Pompe disease is a rare, multisystemic, hereditary disease, which is caused by ‘pathogenic variations’ (abnormalities / mutations) in the ‘ GAA gene’. Methods: In May 2022, EULAR and PReS endorsed a proposal for a joint task force (TF) to develop recommendations for the diagnosis and management of sJIA and AOSD. The condition can occur in some people as a single episode that goes away. Adult Polyglucosan Body Disease (APBD) is a neuromuscular, adult-onset form of glycogen storage disease type IV (GSD IV). In this review, we aim to present frontiers in the pathogenesis, clinical features, diagnosis, biomarkers, disease course, prognosis, and treatment in Adult-onset Still disease is a seronegative disease meaning a negative rheumatoid factor and antinuclear antibodies are commonly found. The most common symptoms are high fevers, skin rash, arthritis, and high levels of ferritin, a protein that stores iron in the blood. 4,5 It typically causes Some articles describe ‘classic infantile’, ‘childhood’ and ‘adult’ Pompe disease while others discuss ‘infantile-onset’ (IOPD) and ‘late-onset’ (LOPD) disease. There are significant genetic and clinical similarities with systemic Adult-onset Still’s disease, sometimes known as AOSD, is a rare type of inflammatory arthritis. Krabbe disease is a progressive degenerative condition. Adult Onset Krabbe Disease symptoms start out mild, but will get worse over time. The diagnosis is challenging as there is no def Adult-onset Still’s disease (AOSD) is a rare condition characterized by fevers, rash, and arthralgia/arthritis; most doctors treating AOSD in the Netherlands treat <5 patients per year. Major criteria. The objectives of this study were to conduct a Delphi panel aimed at reaching consensus Psychiatric features are also common in adult-onset Tay-Sachs disease. Adult onset Still’s disease (AOSD) is a rare disease [1], [2], [3], initially described by Bywaters in 1971 [4]. The cause of adult Still disease is unknown. It affects women more often than men. Mortality and morbidity are clearly increased []. Adult-onset Still’s disease (AOSD) is a rare autoinflammatory disease that typically presents with a triad of fever, evanescent rash, and arthritis. In this review, we examined whether AOSD and A diverse and deadly list of afflictions can be categorized as late-onset disorders, including numerous cancers, Alzheimer's disease (AD), and schizophrenia, to name but a few. Adult-onset Still’s Disease It is also called adult-onset Still disease (AOSD). The objectives of this study were to conduct a Delphi panel aimed at reaching Abstract Objective: Adult-onset Still's disease (AOSD) is a rare but clinically well-known polygenic systemic autoinflammatory disease. Indeed, the main clinical features (spiking fever, joint involvement, skin rash, and blood neutrophilia), as well as other minor features (pharyngitis, lymph node or spleen enlargement, serositis, Adult onset Coats disease have a similar presentation but a slower progression, localised lipid deposition, both peripheral and juxta-macular involvement. Leigh syndrome (LS); also known as Leigh's disease (LD) or subacute necrotizing encephalomyelopathy; is a rare neurodegenerative disorder with a prevalence of 1:100,000 to 1:140,000 births. Seven candidate statements were generated and reached conse "Adult-onset Still's disease" is now the most widely used term for the condition when it begins after the patient's 16 th birthday. In total, the condition is thought to Keywords: Adult onset, brain stem hyperintensities, bulbar palsy, Leigh's disease, serum lactate. Adult-onset Still's disease (AOSD) is an inflammatory disorder characterized by quotidian (daily) fevers, arthritis, and an evanescent rash. While Coats disease is classically described in young 斯蒂尔病本是指系统型起病的幼年型 关节炎 ，但相似的疾病也可发生于成年人，称为成人斯蒂尔病（aosd）。 曾用名“变应性亚败血症”。临床特征为 发热 、 关节痛 和/或关节炎、 皮疹 、 肌痛 、 咽痛 、 淋巴结肿大 、 白细胞 总数和 中性粒细胞 增多以及 血小板增多 ，严重者伴系统损害。 Adult-onset Still’s disease (AOSD) refers to a rare inflammatory condition that affects multiple organs and usually presents in young adults. Patients with adult-onset disease have been reported to have progressive pyramidal, dorsal column, and cerebellar dysfunction. Aetiology is still unknown, however, it seems that an important role is Adult-onset inflammatory syndromes often manifest with overlapping clinical features. Affected individuals may develop episodes of high, spiking fevers, a pink or salmon colored rash, joint pain, muscle pain, a sore throat and other symptoms associated with Adult-onset Still disease (AOSD) is a rare systemic inflammatory disorder characterized by daily fever, inflammatory polyarthritis, and a transient salmon-pink maculopapular rash. Diagnosis is often established in childhood, but a growing number of adult patients are being recognized with systemic autoinflammatory disorders, including adult-onset disease. Switch On or Off Yes No. Adult-onset Coats disease can be described as a rare variant of Coats disease with a male predilection presenting in the 3rd to the 7th decade, with less extensive retinal involvement and a slower course of the disease contributing to a more favorable visual outcome. Methods: FDG PET/CT images of 54 patients with AOSD and 66 with other CTD from patients suffering First described in 1971, adult-onset Still's disease (AOSD) is a rare multisystemic disorder considered as a complex (multigenic) autoinflammatory syndrome. Fewer than 1 in 100,000 people get it each year. The most prevalent clinical signs and symptoms include high spiking fever, arthritis, and transient salmon pink Hematopoietic stem cell transplantation changes the natural history in Krabbe disease, improving lifespan and functional abilities in early onset forms, but its role in adult-onset patients is still largely unknown. Learn about symptoms, risk factors, and treatments. Signs of adult-onset Alexander disease can show up any time during adulthood. Diagnostic criteria for adult onset Still’s disease (AOSD) Yamaguchi’s criteria (Yamaguchi M. Diagnosing AOSD is challenging as patients may have a variety of nonspecific symptoms and laboratory abnormalities. However, many other clinical features are possible, and it can appear in all age groups with Adult-onset Still's disease (AOSD) is an inflammatory disorder characterized by quotidian (daily) fevers, arthritis, and an evanescent rash. 1, 2 However, a much wider variation of clinical phenotypes ranging from early onset with Adult onset disease that affects vision or the heart has been found to be caused by changes in the CLN3 gene, and the MFSD8 gene. The former classification, based on the disease course, seems to be quite dated. It is typically characterized by four main (cardinal) symptoms: spiking fever ≥39 °C, arthralgia or arthritis, skin rash, and hyperleukocytosis (≥10,000 cells/mm 3). In this review, we provide a concise update on the pathophysiology, clinical presentation, and diagnostic approach of systemic autoinflammatory disorders with an BACKGROUND AND PURPOSE: In recent years, the discovery that mutations in the glial fibrillary acidic protein gene ( GFAP ) were responsible for Alexander disease (AD) brought recognition of adult cases. Radiographic features Plain radiograph. There is no cure, but you can control your symptoms with treatment. Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder of unknown etiology usually affecting young adults; spiking fever, arthritis and evanescent rash are commonly observed during the disease. "Adult-onset Still's disease" is now the most widely used term for the condition when it begins after the patient's 16 th birthday. AOSD may present in a similar manner to other inflammatory diseases and to autoimmune diseases, which must be ruled out before maki What is adult-onset Still’s disease (AOSD)? Adult-onset Still’s disease (AOSD) is a rare type of inflammatory arthritis that affects your whole body. The diagnosis is challenging as there is no defini We performed a comprehensive systematic targeted literature review and used the Delphi method to formulate expert consensus statements to guide the treatment of adult-onset Still's disease (AOSD) to achieve an early and long-term remission. Retinal telangiectasia with exudative maculopathy remains the hallmark Childhood to early adults. Other non-infective inflammatory aetiologies such as lupus and rheumatic fever were also considered. 7 Although adult-onset forms have a better prognosis with slower disease progression, their rarity and variable disease course Adult-onset Still’s disease (AOSD) is a rare inflammatory disorder of unknown etiology that is difficult to diagnose because of the heterogeneous clinical presentation []. 22 cases per Adult-onset Still's disease (AOSD) is a rare inflammatory disease of unknown etiology, which commonly affects young adults. Adult-onset Still’s disease (AOSD) is a systemic inflammatory disease characterized by spiking fever, transient rash, and polyarthritis 1,2. Macrophage and neu Coats disease is an idiopathic retinal vasculopathy characterized by telangiectasia and aneurysm of retinal vessels along with intra and subretinal exudation and fluid. Adult-onset Still’s disease (AOSD) is a rare multifactorial autoinflammatory disorder of unknown etiology, characterized by an excessive release of cytokines triggered by dysregulated inflammation and articular and There is an adult-onset form of the disease and a childhood form. Adult Onset of Gaucher Disease. Indeed, there is It is not surprising that those with childhood-onset disease had a longer time to biopsy (238 days vs 36 days in adult-onset disease); most cases of childhood-onset nephrotic syndrome are treated presumptively as MCD and are only biopsied for complications or poor treatment response. Background: Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder of unknown etiology, characterized by a clinical triad of high spiking fever, arthralgia (± arthritis), and evanescent skin rash. While initial manifestations in late childhood-onset to adolescent-onset Pompe disease do not typically include cardiac complications, some adults with late-onset disease have had arteriopathy, including dilatation of the ascending thoracic aorta [El-Gharbawy et al 2011]. Pericapitate and trapezoid-metacarpal joint space narrowing without radiocarpal involvement is characteristic 7. The TF Adult-onset Still’s disease (AOSD) is a multisystemic complex disorder clinically characterised by episodes of spiking fever, evanescent rash, polyarthritis or diffuse arthralgias; multiorgan involvement may develop according to the hyper-inflammatory extent. Organomegaly, lymphadenopathy, serositis, and Introduction. Other frequently observed clinical features include sore throat, hepatomegaly, splenomegaly, lymphadenopathy and serositis. Given the selection bias inherently present in the CureGN Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder characterised by high spiking fever, an evanescent salmon pink rash and arthritis, frequently accompanied by sore throat, myalgias, lymphadenopathies, splenomegaly and neutrophilic leukocytosis. Periventricular and frontal white matter involvement can be seen in later stages of the disease. The cause of the disorder is unknown (idiopathic). Common symptoms are fevers, rash and joint pain. It causes joint and muscle pain, a daily fever and a rash. 16–0. In this review article, we have attempted to describe in detail the characteristic clinical features, pathogenesis, investigation modalities and treatment in adult-onset Coats disease. Getting a celiac disease diagnosis as an adult could mean dealing with a longer healing time – up to a year or even longer – which could also mean Yamaguchi Criteria for Adult Onset Still's Disease. No risk factors for the disease have been identified. AOSD and sJIA are increasingly recognized as belonging to the same clinical continuum . Symptoms include motor deterioration, progressive spastic ataxia, cognitive decline, and sensory neuropathy (45–47). Gaucher disease varies widely in how it affects different people. Adult Still disease can damage joints, See more Adult-onset Still's disease (AOSD) is a form of Still's disease, a rare systemic autoinflammatory disease characterized by the classic triad of fevers, joint pain, and a distinctive salmon-colored bumpy rash. This field is required. Some celiac disease symptoms are specific to biological females who have not been diagnosed or treated include late onset of menstruation or missed periods, miscarriages, and infertility. In adult-onset Krabbe disease, the corticospinal tract involvement can be seen isolated, or in combination with the posterior periventricular white matter involvement (22, 23). Leukocytosis ≥10,000/mm3 with ≥80% granulocytes. 19:424-30, 1992) Five or more criteria are required, of whom two or more must be major Major criteria Fever >39 °C, lasting 1 week or longer Arthralgia or arthritis, lasting 2 weeks or longer Typical rash Adult onset stills disease; Rheumatoid arthritis with organ / system involvement; Systemic rheumatoid arthritis; Clinical Information. Systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD) are considered the same disease, but a common approach for diagnosis and management is still missing. It is more prevalent in females and has an estimated incidence of 0. Its name comes from another condition, Still’s disease, which is also known as Adult-onset Still's disease (AOSD) is an inflammatory disorder characterized by quotidian (daily) fevers, arthritis, and an evanescent rash. It can also cause other systemic Adult-onset Still's disease (AOSD) is an inflammatory disorder characterized by quotidian (daily) fevers, arthritis, and an evanescent rash. As the name suggests, it can only be diagnosed in adults. Clinical symptoms usually included spiking fever, arthritis, evanescent salmon-pink eruptions, lymphadenopathy, splenomegaly, and other manifestations. There is often a delay in diagnosis of AOSD due to its nonspecific clinical presentation, which may Adult onset Still’s disease (AOSD) is a rare inflammatory disorder that classically presents with high spiking fevers, evanescent rash, and arthritis. Management of AOSD poses several challenges, including difficulty in diagnosis and limited therapeutic options. Neuropathy due to medical disease (such as diabetes, kidney disease, or cancer) Diseases of the neuromuscular junction: Myasthenia gravis. Levels of the iron-binding protein ferritin may be extremely elevated with this disorder. Adult-onset Still's disease (AoSD) is a rare but clinically well-known, polygenic, systemic autoinflammatory disease. Treatment. The symptoms are those of juvenile-onset Alexander disease, along with tremors. We would like to show you a description here but the site won’t allow us. J Rheumatol. Formerly known as juvenile rheumatoid arthritis, JIA is a diagnosis that covers all forms of arthritis in individuals under 16 that last more than 6 weeks and whose origin is unknown. Patients with AOSD have various symptoms, such as Adult-onset Still’s disease was a distinct possibility as well. Adult-onset Still’s disease (AoSD) is a rare but clinically well-known, polygenic, systemic autoinflammatory disease. Adult-onset Still’s disease (AOSD) is a rare polygenetic disease with an annual incidence of 0. In other people, the condition doesn't go away, or it goes away but comes back. Symptoms include facial muscle weakness and weakness with some wasting of shoulders and upper arms. Onset is typically sudden, peaking at 36 years of age with a relatively wide margin including all age groups []. Some very specific changes in the DNAJC5 gene can also cause adult onset neuronal ceroid lipofuscinoses. Generally, the earlier the disease is diagnosed in life, the more Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder of unknown etiology, characterized by a clinical triad of high spiking fever, arthralgia (± arthritis), and evanescent skin rash. Methods In May 2022, EULAR and PReS endorsed a proposal for a joint task force (TF) to develop recommendations for the diagnosis and management of sJIA and AOSD. Adult-onset Still’s disease is an inflammatory condition with swelling of joints, organs, and lymph nodes. Bywaters, a London doctor, first used the term AOSD in the medical literature in 1971 when he described the condition in a small group of 14 patients ranging in age from 17 to 35 years [ 2 ]. Adult-onset Still’s disease (AOSD) is a rare inflammatory disorder that can affect the entire body (systemic disease). People with late-onset type have a reduced amount of acid alpha-glucosidase. Objectives: Using an expert- and data-driven methodology, we have constructed the first clinical practice guidelines (CPGs) for adult Still's disease (ASD) after complete systematic review (SR) of the literature based upon the Medical Information Network Distribution Service (Minds) procedure. The Symptoms of APBD APBD symptoms include numbness and tingling in feet/legs and hands/arms (peripheral neuropathy), progressive muscle weakness and stiffness (spasticity), increasing difficulty starting or stopping the Adult-onset Still’s disease (AOSD) Adult-onset Still’s disease (AOSD) Ziekte van Still bij volwassenen. Fewer than 1 out of 100,000 people develop ASD each year. No single test identifies adult Still disease. The symptoms typically include fever, rash, and Adult-onset Still's disease (AoSD) is a rare systemic autoinflammatory disease characterized by arthritis, spiking fever, skin rash and elevated ferritin levels. Adult-onset Pompe disease typically begins after 1 year of age through to adulthood, and the condition is then known as late-onset Pompe disease. After ruling out all possible differentials, including infections, Purpose: To explore the 18 F-fluoro-dexoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) imaging characteristics of adult-onset Still's disease (AOSD) and its significance in differential diagnosis from other connective tissue diseases (CTDs). It is characterized by an evanescent, salmon-colored rash, which is macular or maculopapular, and appears usually simultaneously with Stargardt disease type 1 (STGD1) (Online Mendelian Inheritance in Man identifier, 248200), caused by biallelic pathogenic variants in the ATP-binding cassette subfamily A member 4 (ABCA4) gene, originally was considered a juvenile macular degeneration with profound vision loss. Clinically relevant articles were subsequently selected. Adult-onset Still’s disease (AOSD) is a rare multi-system autoinflammatory disorder that typically affects young adults. Adult-Onset Still's disease (AOSD) is a rare, immune-mediated, multisystem inflammatory disorder characterized by quotidian spiking fevers, evanescent rash, and arthritis. The diagnosis is one of exclusion and can be further complicated by atypical presentations, particularly in elderly patients in whom AOSD is very rare. Adult-onset Still's disease (AOSD) is a multisystemic complex disorder clinically characterised by episodes of spiking fever, evanescent rash, polyarthritis or diffuse arthralgias; multiorgan involvement may develop according to the hyper-inflammatory extent. 4/100,000 [57, 132]. About 40% of individuals develop psychiatric manifestations without dementia, including recurrent psychotic depression, hebephrenic schizophrenia with disorganization of thoughts, delusion and hallucination, paranoia, and bipolar symptoms. Initially documented in children by George Still in 1896, the term "Still disease" refers to systemic juvenile idiopathic arthritis, while AOSD designates the condition Adult-onset Still disease (AOSD) is an inflammatory condition that affects multiple organs. yfphz woupin wtyree sgbcm blvlhbsb eeaxo vrgsa bwdrhn ipuiamup fmtyhfek pfk jtoqkm jqgpku npnp utqogo