Dysport dilution. The dilution methods are specific to this toxin.

What Dysport is used for: Adults: Dysport is used in adults to treat muscle spasms: • Around the eyes • In the face • In the neck • In the arm and shoulders • In the leg Dysport is also used in adults to treat: • Hyperhidrosis. The dilution methods are specific to this toxin. The biggest difference comes in the formulations of both injectables. 08 mL (20% decrease in Dysport 300-Unit Vial: Recommended dilution options1 Dysport 500-Unit Vial: Recommended dilution options1 2. Which looks more natural BOTOX® or Dysport? Dysport is composed of smaller molecules, which may allow it to spread to a wider area and provide a more natural-looking result. 9% sodium chloride injection. g. e. The dilution ratio of Dysport® in the three included studies were 200U/mL ; 125U/mL, 250U/mL, 375U/mL ; 133U/mL, 200U/mL . Administration: Dysport should only be injected by appropriately trained physicians. A decrease or increase in the DYSPORT dose is also possible by administering a smaller or larger injection volume (i. 3 to 4 hours; Faculty observes you during injection treatment sessions; Apr 21, 2021 · 4. These potential side effects or complications include injection site discomfort, headache, bruising, swelling, eyelid droop (ptosis), local reactions, systemic reactions, and unsatisfactory cosmetic results. Die zuzugebende Menge iso-toner Natriumchloridlösung ist für Dysport 300 Einheiten und Dysport 500 Einheiten verschieden. (The proteins are mostly there to stabilize the toxin and improve absorption, Dr. For the injection, Dysport will be dissolved in 0. Both Dysport and Botox are effective in reducing moderate to severe wrinkles and fine lines. In-person or virtual mentorship on Dysport injection, dosing and dilution, and appropriate use. BUT – since Dysport is not as concentrated as Botox and Xeomin, it actually takes 2-3 times more units of Dysport to achieve the same therapeutic effect as Botox and Xeomin. , Royal College of Physicians). Sep 28, 2023 · DYSPORT is supplied as a dry powder, in single-dose 300 Unit and 500 Unit vials, which must be reconstituted with preservative-free 0. Five syringes are drawn up and each will contain 0. Three hundred units of abobotulinumtoxinA (Dysport®) may be diluted in 0. 9% sodium chloride injection to yield a solution of Dysport with a concentration equivalent to 200 units in 1 ml. The study evaluated a total of 208 patients who had a diagnosis of spasticity due to cerebral palsy, were either toxin DYSPORT is intended for intramuscular injection only. 1 * Diluent is sterile, Preservative-free 0. Administer Dysport within 4 hours of reconstitution. Azzalure is indicated for the temporary improvement in the appearance of moderate to severe glabellar lines (vertical lines between the eyebrows, or “frown lines”) seen at frown and lateral canthal lines (crow’s feet lines) seen at maximum smile, in adult patients under 65 years, when the severity of BICEPS BRACHII Dysport 200 to 400 Units. 9% NaCl/H 2 O produces volumes that are easily injectable and adequate in relation to the target muscle volume. 35 ng per 500 U vial of Dysport (correcting an earlier publication stating 12. Here I’m showing the most common dilutions with the most common syrin Dec 22, 2022 · What really sets Dysport apart is its spreadability. Dysport is used in the Feb 15, 2001 · In terms of clinical efficacy in humans, 1 U of Botox is estimated to be equal to 3 to 4 U of Dysport, the product used in our study. For further information see Section 4. In the open-label extension, the SOCs and PTs most frequently associated with TEAEs were infections and infestations, followed by general disorders and administration site conditions, respiratory, thoracic and mediastinal disorders, gastrointestinal disorders and musculoskeletal and connective tissue disorders. 2. 0 mL 2. However, this dilution has resulted in more cost effectiveness. 00/Unit. If you think your patients may benefit from having a Dysport injection specialist on their care team, start your search today. A dilution of 100 MU of ONA/INCO in 2. Joe Niamtu, III DMD. Dysport is a local muscle relaxant (or neuromuscular blocking agent) adapted from the botulinum neuromodulator type-A and is used in both aesthetic and therapeutic indications. Sep 30, 2023 · DYSPORT is supplied as a dry powder, in single-dose 300 Unit and 500 Unit vials, which must be reconstituted with preservative-free 0. 0 mL* Diluent per Dysport 300-Unit Vial Resulting Dysport Units per 0. 05 mL (50% decrease in dose), 0. ) Dec 13, 2018 · The total Clostridial protein content of the three main commercially available BoNT-A products—Dysport ®, Botox ®, and Xeomin ® —has been previously reported in the literature, giving values of 5 ng per 100 U vial of Botox, 4. Jun 25, 2023 · Dysport is meant for use on the vertical lines that form between the eyebrows (glabellar lines). Please like and subscribe! IG: nurse_marisa_ Note: These dilutions are calculated for an injection volume of 0. 5mL of saline (120 to 500 U/mL). While 50 units of Botox® costs $500, 125 units of Dysport® costs $450. 5 ml 0. 5 mL 3. The Dysport is cheaper than Botox because of the dilution in Dysport. Table 1 provides dilution instructions . 6 mL 1. 0 mL Note: These dilutions are calculated for an injection volume of 0. 1 mL; Note: These dilutions are calculated for an injection volume of 0. Both products are reconstituted the same way: 1 ml of preserved saline to 1 vial. Apr 1, 2024 · Dysport® (abobotulinumtoxin A) is a botulinum toxin recently indicated in the treatment of neurological detrusor overactivity secondary to spinal cord injury or multiple sclerosis, in patients with intermittent self-catheterization. 0 mL of diluent should be used. 0 mL* 100 Units Diluent per Dysport 300-Unit Vial Resulting Dysport Units per 0. Daher wird empfohlen, bei Lang-zeitbehandlung nicht zwischen unter-schiedlichen Clostridium botulinum Toxin-Präparaten zu wechseln. One vial of Botox has 100 units and one vial of Dysport has 300 units. 5. 5 mL 120 Units 3. 3mL 0 of reconstituted solution) of DYSPORT, to be divided into 3 injection sites; 10units (0. 25/Unit, while Botox and Xeomin are priced higher at ~$12. What Dysport is and what it is used for Dysport is a medicine that blocks the transmission of nerve impulses to the muscle or sweat glands so that spasms in the muscle or sweat production is reduced. The units are slightly different due to different standards from different laboratories. Exercise caution when administering to patients with surgical alterations to facial anatomy, excessive weakness or atrophy in the target muscle(s), marked facial asymmetry, inflammation at the injection site(s), ptosis, excessive dermatochalasis, deep dermal scarring, thick sebaceous skin or Feb 26, 2021 · This generates and determines a dilution effect. Dysport 50 Units Dysport 25 Units Dysport 20 Units 1. With Dysport the same is true and it can be diluted to different strengths. Possible side effects 5. Dysport während einer Behandlungssit-zung angewendet werden, muss darauf geachtet werden, die korrekte Menge an Lösungsmittel zur Auflösung zu ver-wenden. 1 mL. Table 1 provides dilution instructions Azzalure is the aesthetic version of Dysport for the European Union member states. 5 ml of 0. How to use Dysport 4. 08 mL (20% decrease in Oct 10, 2020 · Dysport is priced at an apparent bargain price of ~$4. Recommended: 1 to 2 injections per muscle. While this isn’t a problem for some people, it is essential to consider that three Dysport units equal about one unit of Botox. , treatment of hyperhidrosis, dilutions should not vary to increase patient safety. %PDF-1. . Note: These dilutions are calculated for an injection volume of 0. Doft says. , 0. 0 mL Safety results in adult cervical dystonia . 0 mL* 100 • For additional information, refer to Table 1: Dilution Instructions for Dysport Vials (500 Units and 300 Units) in package insert Section 2. See how to properly prepare Dysport for administration for pediatric patients with upper or lower limb spasticity. 08 mL (20% decrease in dose) or 0. 0 cc. 5 ng per 500 U vial), and Xeomin Dysport Therapeutic dosing for spasticity in pediatric patients is based on Units per kilogram of body weight. Higher conversion ratios may lead to an overdosing of Dysport, with a potential increased incidence of adverse events. foryourbestself. 9% Sodium Chloride Injection, USP. DILUTION. 5 mL of preservative-free saline solution (0. “Many people report that it lasts longer than other neuromodulators," says Dr. The ratio: 1 ml of preserved saline : to one vial of Dysport (300 How Dysport is given How to use it Your doctor will make up and give you the injection. An injection volume When fully reconstituted, Dysport should be a clear, colorless, and particulate-free solution. However, a single Botox unit’s potency is nearly three times stronger than Dysport. Includes reconstitution instructions and diluent amounts for both the 300-Unit and 500-Unit vials. 2 Preparation of DYSPORT Solution for Administration DYSPORT is supplied as a dry powder, in single-dose 300 Unit and 500 Unit vials, which must be reconstituted with preservative-free 0. Do not freeze reconstituted Dysport. We use 3 IU !!! To put that in English, we use 33% more than someone injecting the 2 IU dilution and 17% more than the recommended dosage. The package insert of onabotulinumtoxinA (Botox®) recommends dilution of 100 units in 1 to 8mL of saline (12. Dysport® is diluted more than Botox®. DYSPORT is contraindicated in patients with known hypersensitivity to any botulinum toxin products, cow’s milk protein, or to any of the components in the formulation, or infection at the proposed injection site(s). Do not receive a Dysport injection if: you are allergic to Dysport or any of its ingredients, or cow’s milk protein; you had an allergic reaction to any other botulinum toxin product, such as Myobloc®, Botox®, or Xeomin®; or you have a skin infection at the planned injection site. Dysport darf nur von Ärzten angewendet www. Contents of the pack and other information 1. 1 mL Resulting Dysport Units per 1. 5 mL 2. However, more Dysport units may be required to achieve the same results as Botox. 1 Dysport helps them look consistently natural—not frozen—because it allows the untreated facial muscles to work normally, which in turn helps patients freely show facial expressions in untreated areas. Skin Caution should be exercised when administering DYSPORT AESTHETIC™ to patients with Strategy 2. 1 mL Diluent * per 300 Unit Vial Resulting Dose Units per 0. The authors concluded that substantial savings could be realized by using Dysport to treat upper limb spasticity. The article discusses the available evidence on the conversion ratio between Dysport and Botox in adults affected by spasticity, cervical dystonia 3. Table l: Dilution Instructions for DYSPORT Vials (500 Units and 300 Units) 2. Dysport is not interchangeable with other botulinum toxins, and the potency units are not the same 1 †When econsr i t tuting a 500-Unit vial of Dysport in preparation for dilution, no more than 2. 5cc of Saline to each vial of Botulinum Toxin as suggested in the package insert for a total of 40 units per 1. Into the first 10 mL syringe draw all of The safety of DYSPORT for the treatment of hyperhidrosis has not been established. Injection site infection. Dysport is given by intramuscular injection. com Botox & Dysport come in a powder and then we add saline to it before injection the same day. 4 Dosing in Spasticity in Adults Dosing in nitlal and subsequent treatment sessions should be tailored to the individual based on the Size, number and location of muscles involved, severity of spasticlty, he The Dysport Injector Locator is designed to make it easy for patients, caregivers, and referring physicians to find injectors in their area who are trained to administer botulinum toxins, including Dysport. Units shown indicate the average Dysport dose and specific muscles injected. Feb 2, 2022 · “ Dilution Calc” AppEasy to use app for Neurotoxin counting. 6 %âãÏÓ 457 0 obj > endobj 479 0 obj >/Filter/FlateDecode/ID[]/Index[457 54]/Info 456 0 R/Length 102/Prev 649547/Root 458 0 R/Size 511/Type/XRef/W[1 2 1 Contraindications. According to the manufacturer’s instruction, the Nov 2, 2009 · Dysport side effects are the same as for other neuromodulators such as Botox or Xeomin. Dec 6, 2015 · The dilution volume varies widely. In my practice, we use a 2 mL dilution, but this can vary (~1-5 mL) based on physician preference. Nov 22, 2009 · To prepare Dysport for this dilution, 3 cc of preserved saline is added to the 300 unit Dysport vial. Apr 11, 2013 · The optimal conversion ratio between Dysport and Botox—the two botulinum neurotoxin type A products (BoNT-As) supported by the larger bulk of evidence—has been extensively debated, because of its broad medical and economic implications. 5timeslesspotent (activity declined to 39. Dysport also remains effective for 3–4 months before follow In the Botox vs Dysport debate, you’ll come to find that it’s really difficult to compare the two injectables. Modified Ashworth Scale (MAS) score was ≥2 in the primary target muscle group (PTMG) for toxin-naive patients How Dysport is given . This may cause some confusion for clinicians not adept at determining how many units to inject in each anatomical area. Dec 5, 2014 · First, our study shows that Dysport treatment results were not inferior to those from Botox at a conversion factor of 2. Leave a comment if any questions. Dysport is given as an injection in the muscle (intramuscularly), or under the skin (subcutaneously) after dilution, depending on the condition for which you are being treated. Allergy to cow milk protein. 15 mL (50% increase in dose)). Botox is meant for use on glabellar lines, forehead lines, and crow’s feet (laugh lines) around Taken together, the findings retrieved from this literature research suggest that a conversion ratio of 3:1 (Dysport:Botox)--or even lower--can be considered appropriate for the treatment of the above-mentioned conditions. 9% Sodium Chloride Injection USP. 7%) in the saline assay. 5:1 ratio in clinical practice, one vial of Dysport (500 units) corresponds to two vials of Botox (200 units). Before you receive a Dysport injection tell your doctor: Dysport contains the active substance Clostridium botulinum type A toxin-haemagglutinin complex. 5:1. 05 mL of reconstituted When treating excessive sweating, Dysport 500 units is diluted with 2. Table 1 provides dilution instructions for the 300 Unit and 500 Unit vials, depending on the desired final concentration. 5 units of dysport per unit of botox to get similar results. The added spreadability can slightly increase the risk of the product unintentionally affecting the eyelids and eyebrow if administered by an Jul 28, 2019 · Wouldn't it be great if you didn't have to do mental math gymnastics when switching back and forth between Botox and Dysport? In this short video I'll show Contraindications. 5 mL, providing a total of 600 U of reconstituted Dysport. 9 % sodium chloride for injection). Adverse Reactions Oct 11, 2021 · For some people, Dysport may kick in faster than other injectable neurotoxins. , curare-like For the mouse assay used to standardize each batch of Dysport, the toxin is diluted in a phosphate buffer containing gelatine that stabilizes the toxin at low concentrations, whereas saline is used as the diluent for the Botox assay, which gives a loss of potency because of dilution artefacts. The conversions is about 2. Watch Now Dysport tends to be less expensive per unit than Botox. This can make it easier to treat larger areas as it means fewer injections are required. 6 mL 500 Units 1. For the treatment of focal spasticity, Dysport can also be administered by healthcare professionals having received appropriate training and qualification in accordance with national guidelines (e. When using the 2. DYSPORT is approved only for intramuscular injection. 08 mL (20% decrease in Nov 26, 2023 · But there are some notable differences between Botox vs Dysport related to dilution, diffusion, longevity, pricing, and best uses. Simple Dysport Dosing (Table 1) A thorough understanding of Dysport dosing is a pre-requisite for integrative treatment. Sensitivity analyses considering available “real-world” dosing showed consistent results, with Dysport being less costly than Botox in all 19 countries. 2 DOSE AND METHOD OF ADMINISTRATION THE UNITS OF DYSPORT ARE SPECIFIC TO THE PREPARATION AND ARE NOT INTERCHANGEABLE WITH OTHER PREPARATIONS OF BOTULINUM TYPE A TOXIN. The most common side effects are nose and throat irritation, headache, injection site pain, injection site skin reaction, upper respiratory infection, Feb 19, 2011 · Each patient is unique, but in most cases, I will start patients out with approximately 30 Dysport units to the horizontal forehead lines, 60 units to the glabella, and 60 units total to the crow's feet (30 units each side) for a total of 150 Dysport units. Cho, and recent studies by Galderma show that Dysport may last up to five months. Jede Sprit-ze ist entsprechend zu kennzeichnen. This was first shown by Hambleton and Pickett,4 who measured different samples of Botox and Dysport usingthetwoassays:aBotoxunitwasapproximately 3 times more potent in the Dysport assay, and a Dysportunitwasapproximately2. In Dysport and Botox are both mixed with sterile, injectable saline to make them liquids, so that they may be injected. Caution should be exercised when DYSPORT is used where the targeted muscle shows excessive weakness or atrophy. I find it more logical to think directly in Dysport Units, with 10 DU being a May 14, 2023 · No study has assessed the effects of the incorporation of isolated lidocaine into botulinum toxin for reducing its pain or complications. Diluent is sterile, preservative-free 0. Cosmetic Facial Surgery Mar 4, 2016 · The difference was 20% or higher in nearly half (47%) of the countries. Dosing of Dysport is easily mastered, whether you prefer to think directly in Dysport Units (DU) or to convert from Botox Units (BU). When administering Dysport in adult spasticity, re-treatment should occur Natural looking Dysport provides temporary improvement in the appearance of moderate to severe frown lines that are caused by the activity of the procerus and corrugator muscles in patients. We believe that looking your absolute best changes the way you fe Sep 28, 2023 · Table 1: Dilution Instructions for DYSPORT Vials (500 Units and 300 Units) Diluent * per 500 Unit Vial Resulting Dose Units per 0. 2 Preparation of Dysport Solution for Administration DYSPORT is supplied as a dry powder, in single-dose 300 Unit and 500 Unit vials, which must be reconstituted with preservative-free 0. The important thing to understand is that it is not the dilution but rather the number of units injected which affects your result. Your doctor will make up and give you the injection. 0 mL 0. How to store Dysport 6. 5 IU. The efficacy and safety of Dysport were evaluated in a randomized, multicenter, double-blind, placebo-controlled study in 238 adults with upper limb spasticity (ULS) who were at least 6 months post-stroke or post-traumatic brain injury. Before you receive a Dysport injection tell your doctor: Explore Dysport® pediatric spasticity safety data. There is no such thing as a treatment be Dysport is a prescription injection for temporary improvement in the look of moderate to severe frown lines between the eyebrows (glabellar lines) in adults less than 65 years of age. Studies on the dilution of botulinum toxin with other Dysport ® has a wide FDA-approved dosing range, allowing for flexibility to customize subsequent doses based on patient response,. However according to personal preference, it can be mixed witjh 1-5 cc. Study design for adult upper limb spasticity . Once reconstituted, Dysport should be stored in a refrigerator (2-8° C; 36- 46° F), protected from light, and used within four hours. Dysport is indicated for the temporary improvement in the appearance of moderate to severe glabellar lines associated with procerus and corrugator muscle activity in for the 300 Unit and 500 Unit vials, depending on the desired final concentration. To find out more about Botox, Dysport and cosmetic facial surgery in Richmond, Virginia visit www. Hypersensitivity. Oct 9, 2019 · What is the reconstitution ratio for Botox/Dysport? Many practitioners ask if Dysport is reconstituted differently than Botox. com. Unless for special indications, e. 5:1, the adverse event profile was similar in the treatment of CD. 08% (20% decrease in dose) or 0. 20,33,34 On the basis of previously reported clinical Study design for pediatric upper limb spasticity . The efficacy and safety of Dysport were evaluated in a randomized, prospective, double-blind, multicenter, low-dose controlled, multiple treatment study with pediatric patients aged 2 to 17 with upper limb spasticity (ULS). Dysport is much more diluted and spreads quickly compared to Botox. 2: Preparation of Dysport Solution for Administration1 Drug Interactions Co-administration of Dysport and amino-glycosides or other agents interfering with neuromuscular transmission (e. lovethatface. Table 1: Dilution Instructions for DYSPORT Vials (500 Units and 300 Units) Diluent* per 500 Unit Vial DYSPORT AESTHETIC™ Product Monograph Page 6 of 25 The potential risk of localised muscle weakness or visual disturbances linked with the use of DYSPORT ™ AESTHETIC may temporarily impair the ability to drive or operate machinery. Dysport spreadability. Dysport Product Information: Version 6, 21 July 2020 2 4. The extra dilution of Dysport means it tends to spread slightly further than Botox. To calculate the total units of Dysport Therapeutic required for treatment of one limb, select the dose of Dysport Therapeutic in Units/kg and the body weight (kg) of the patient (Tables 3 and 4). FAQ Die Einheiten von Dysport sind spezifisch für das Präparat Dysport und dürfen nicht auf andere Präparate mit dem Wirkstoff Clostridium botulinum Toxin übertragen werden. Cautions. Second, at the ratio of 2. 1 * AN APPROACH FOR THE DILUTION OF DYSPORT® (abobotulinumtoxinA ) Dysport 50 Units Dysport 20 Units Dysport 12 Units Dysport 10 Units Dysport 500 Units Dysport 200 Units Dysport 120 Units Dysport 100 Units 0. Jan 24, 2016 · The products are very similar. 6 to 2. 7 %âãÏÓ 199 0 obj > endobj 243 0 obj >/Filter/FlateDecode/ID[1C6DF0E8C29EA3C62379675075C69F46>69243412F2173C4BB700B774AD561443>]/Index[199 106]/Info 198 0 Sep 30, 2023 · DYSPORT is supplied as a dry powder, in single-dose 300 Unit and 500 Unit vials, which must be reconstituted with preservative-free 0. Pooled double-blind trials: below are the most common adverse reactions (≥5%) and greater than placebo in adult patients with cervical dystonia (CD) who received Dysport (500 Units, n=173). Dysport may create a more natural look than other neuromodulators. Pre-existing Conditions at the Injection Site. 2 This will result in two 10 mL syringes, each containing 7. 9% Sodium Chloride Injection, USP using aseptic technique prior to intramuscular injection. 5 mL 200 Units 5. May 14, 2022 · This DILUTIONCALC app is no longer available for downloads but still works on my phone. Some physicians use 2 IU (international units) dilution, the package insert recommends 2. The dose used is 600 or 800 units. Reconstitution instructions are specific for each of the 300 Unit vial and the 500 Unit vial. IM Focal spasticity Adult Upper limb: Doses of 500-1,000 u divided among selected muscles: Flexor carpi radialis, flexor carpi ulnaris, flexor digitorum profundus, flexor digitorum superficialis, flexor pollicis longus, brachioradialis, pronator teres: 100-200 u; adductor pollicis: 25-50 u; brachialis, biceps brachii: 200-400 u; triceps brachii, pectoralis major, subscapularis, latissimus The recommended dose per side is 30units (60 units for both sides, 0. 5 to 100 U/mL). The desired final concentration after dilution varies depending on the indication (see Table 2 for the recommended solution concentration after dilution). Table 1: Dilution Instructions for DYSPORT Vials (500 Units and 300 Units) Diluent* per 500 Unit Vial Jun 2, 2010 · Answer: Botulinum Toxin (Dysport or Botox) dilution and preparation We use 2. As Dr. 2, Posology and method of administration, in the Summary of Product Characteristics. and 100 Xeomin and 2 ml standard for 300 U Dysport because we believe this is an optimal concentration for most areas of the face when placed in the muscles Pediatric Spasticity Dosing and Dilution Webinar . Oct 23, 2023 · On average, Dysport may cost slightly less than Botox per treatment area due to the different dilution ratios. For example, Botox costs $10-18 per unit, while Dysport costs $4-7 per unit. 5 mL 200 Units 12 Units 10 Units 50 Units 20 Units 2. Jun 18, 2021 · It is assumed that the greater dilution for larger muscles may produce better therapeutic effects than the low diluted volume, but there has been no evidence to prove it . This is a loss of potency because of dilution artefacts. Training: DYSPORT should only be administered by appropriately trained physicians. Doshi explains, the specific protein used in Dysport has a lower molecular weight than the protein used in Botox, allowing a Dysport injection to diffuse through tissues. Mar 24, 2021 · About APT Medical AestheticsWe are passionate about helping our clients change their lives. Dilution instructions for a dose of 800 U • Using 300 U vials: Reconstitute three 300 U vials each with 1. Sep 30, 2023 · Note: These dilutions are calculated for an injection volume of 0. These volumes yield concentrations specific for the use for each indication (see Table 1). This difference means that you will need to use more units of Dysport to achieve the same results as you would with Botox, and the cost may rival your Dosing and Dilution Dysport offers the flexibility to retreat patients every 12 to 16 weeks or longer, as necessary, based on the return of clinical symptoms. Dysport dosing for adult ULS in the pivotal clinical trial. How to use it . 6 cc or 60 units. wz ai rl ew mt me ts gc mf dh